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Oral, anthelmintic agentUsed for roundworm, hookworm, pinwormAvailable OTC
Pin-X, Pronto Plus Pinworm
Pin-X Oral Susp: 1mL, 144mg
11 mg/kg base (Max: 1 g) PO as a single dose. Retreatment may be necessary after 14 to 21 days. Treatment of the entire household is recommended.
11 mg/kg base PO as a single dose. Retreatment may be necessary after 14 to 21 days. Treatment of the entire household is recommended. Consult physician and do not self-treat.
11 mg/kg base (Max: 1 g) PO once daily for 3 days as an alternative to albendazole or mebendazole.
11 mg/kg base (Max: 1 g) PO once daily for 3 days.
11 mg/kg base (Max: 1 g) PO as a single dose.
†Indicates off-label use
11 mg/kg/dose PO, not to exceed 1 g/dose PO.
2 years and older: 11 mg/kg/dose PO, not to exceed 1 g/dose PO.1 year: 11 mg/kg/dose PO has been used off-label.
11 mg/kg/dose PO has been used off-label.
Safety and efficacy have not been established.
Self-treatment is not recommended.
Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed.
Pyrantel is administered orally.May administer with food, milk or fruit juice, at any time of day.Fasting, purgation, or special diets are not necessary for effective treatment.
Shake well before use.Liquid products can be mixed with milk or fruit juice. Measure liquid products with a calibrated oral dosing device to administer an accurate dosage.
Pin-X:- Store at room temperature (between 59 to 86 degrees F)Pronto Plus Pinworm:- Store at room temperature (between 59 to 86 degrees F)
Pyrantel should be used with caution in patients with hepatic disease.
Pyrantel chewable tablets contain phenylalanine; use with caution in patients with phenylketonuria.
Pyrantel is poorly absorbed from the GI tract. There are no well controlled studies of pyrantel use in pregnant women. Use pyrantel with caution during pregnancy. Some experts suggest that single-dose pyrantel therapy may be given to pregnant women. Pregnant women should not take pyrantel unless directed by a doctor.
There are no data regarding the presence of pyrantel in breast milk. Pyrantel is poorly absorbed from the GI tract; therefore, excretion into breast milk may be minimal. Some experts suggest single-dose pyrantel therapy may be given to breast-feeding women. Breast-feeding infant exposure may be minimized if the drug is taken just before the longest sleep interval for the infant.
vomiting / Early / Incidence not knownabdominal pain / Early / Incidence not knownnausea / Early / Incidence not knowndiarrhea / Early / Incidence not knowndizziness / Early / Incidence not knownheadache / Early / Incidence not known
There are no drug interactions associated with Pyrantel products.
By stimulating the release of acetylcholine, inhibiting cholinesterase, and stimulating ganglionic neurons, pyrantel acts as a depolarizing neuromuscular blocking agent in helminths. These actions cause extensive depolarization of the helminth muscle membrane, producing tension of the helminth's muscles, which causes paralysis and release of their hold to the intestinal wall. This action is unlike piperazine, which is a hyperpolarizing neuromuscular blocking agent that relaxes helminth muscles, causing a subsequent detachment from the intestinal wall. Expulsion of the parasites from the GI tract occurs by normal peristalsis.
Pyrantel is administered orally. The absorbed drug is partially metabolized in the liver, with approximately 7% or less of the dose being excreted in urine as unaltered drug and metabolites and more than 50% of each dose being excreted unchanged in the feces. Affected cytochrome P450 isoenzymes and drug transporters: none
Pyrantel has poor and incomplete absorption from the GI tract. Peak plasma concentrations (0.05 to 0.13 mcg/mL) occur within 1 to 3 hours.