REFIVE Clinical Study
All five of the Lifepharm products have been combined into a sealed packet for convenience, freshness, and conservation. The packets contains two Laminine capsules, an OMEGA+++ softgel, an IMMUNE+++ tablet and a DIGESTIVE+++ capsule. There are thirty packets per box.
A clinical study was undertaken at a Health and Wellness Clinic in Diamond Bar, California by a physician to evaluate safety and efficacy of subjects consuming a REFIVE packet for ninety days. Twelve subjects (32-68 yrs.) consumed a REFIVE Packet daily for 90 Days. Subjects signed informed voluntary consent agreements and were given information about each supplement contained in the REFIVE packet. Subjects refrained from taking other dietary supplements and were requested to maintain their normal diet and lifestyle. Subjects were asked to fast the night and morning before blood samples were taken. Blood was drawn at baseline (before taking supplements) then at 30, 60 and 90 days during the treatment. The parameters assessed included a standard comprehensive metabolic panel conducted by Quest Diagnostics. The parameters measured included cholesterol, LDL (low density lipoprotein), non-HDL (non-high-density lipoprotein), dehydroepiandrosterone (DHEA), triglycerides, blood glucose, cortisol, creatinine, and blood urea nitrogen (BUN), including the complete blood count. These were parameters thought to be of value.
Results: Cholesterol, triglycerides, glucose and cortisol were the parameters that showed substantial improvement in the group and thought good indicators on effectivity of the combined supplements. Values of other blood lipoproteins or ratios sometimes showed baseline and treatment values out of normal range and were not included. Creatinine and blood urea nitrogen remained within normal ranges throughout the clinical treatment period indicating safety. DHEA levels remained fairly constant in subjects during the supplementation period. This was a valuable indicator that the products did not affect this steroid hormone. DHEA, as the most abundant steroid hormone, is the intermediate in the synthesis of androgen and estrogen steroids.
Conclusion: It was remarkable that several of the primary health parameters showed fairly consistent positive change in the evaluated groups of participants. A brief questionnaire included comments that bowel regularity was achieved. Overall comments included subjects expressing a sense of well-being with good daytime energy and concentration. Sleeping was mentioned as improved for many of the participants. A night-shift worker and four other participants responded that they seemed stronger and better able to manage stress of work, along with stress of family issues (adult children issues, recently deceased parent, caretaking of elderly or sick parent). All subjects were eager to participate and were compliant in taking the supplements regularly. The subjects' responses were positive and there were no comments or reported unwanted side effects.
85% of Subjects Evaluated Showed Improved Glucose Level Maintenance.
Maintaining healthy blood sugar helps keep blood vessels from becoming damaged as high blood sugar and its side reactions of glycated end products, destroys vascular tissues and increases risks of heart disease and stroke. Controlling high blood sugar improves circulation to such vital organs as the heart, brain, kidneys, eyes, legs, feet and nervous system.
Laminine has been investigated in 2 peer reviewed studies showing that it helped maintain healthy glucose levels as measured by HA1-C when 2-4 Laminine capsules were taken daily for a period of three months. Laminine may be considered as an adjunct supplement for supporting the maintenance of healthy glucose levels while the physician monitors closely blood glucose levels for the individual and they take prescribed medication properly.
71% of Subjects Evaluated Showed Improved Cholesterol Level Maintenance.
Maintaining healthy cholesterol levels helps reduce arterial plaque formation and lowers the risk for heart disease and stroke. OMEGA+++ not only contains a pure and recommended ratio of EPA and DHA source of the Omega 3- fatty acids but CoQ-10 and Vitamin K2. Co-Q-10 helps the metabolic and energy production in the mitochondria of heart muscle cells. Vitamin K2 has been shown to support vascular elasticity because the biochemicals that utilize vitamin K2 as a cofactor, are able to remove calcium from plaque formations and move it back to the bones for better mineralization and bone strength.
100% of Subjects Evaluated Showed Improved Triglyceride Level Maintenance.
High triglyceride levels are an indicator that an individual consumes more calories in the form of carbohydrates than one burns. This excess sugar turns into a type of fat called triglycerides. High triglycerides contribute to hardening and thickening of the artery walls, which increases the risk of stroke, heart attack and cardiovascular disease. High triglycerides are also associated with inflammation of the pancreas.
High triglycerides are associated with obesity and metabolic syndrome, which includes the storage of visceral and body fat at the waistline, high blood pressure, high blood sugar and abnormal cholesterol levels. All of these are indicators for harmful health conditions.
To reduce harmful fats in the blood it is important to exercise, eat a diet low in carbohydrates and animal fat while consuming good fats such as olive oil, fish oils, avocados and nuts. Numerous studies in humans have shown that consuming Omega-3 fatty acids may be supportive to helping maintain healthy triglyceride levels.
FGF2 (fibroblast growth factor-2) in Laminine has been shown to support the function of pancreas cells. The amino acid profile in Laminine also contains amino acids shown to support pancreatic cells.
86% of Subjects Showed Improved Cortisol Level Reduction.
Cortisol is often called a stress hormone indicating that beyond its normal functions in your body, it can be harmfully and continuously elevated. If an individual encounters a perceived threat, such as a large dog barking, a region in the brain sets off an alarm system in the body. Hormones including adrenaline and cortisol are released to respond to this "threat."
Adrenaline increases the heart rate, blood pressure and boosts energy supplies as the body prepares to "fight or flea" the perceived danger. Cortisol increases sugars in the bloodstream to give the brain energy to respond and increases the substances for tissue repair. This is a good survival tool in an alarmed situation.
Higher cortisol alters the immune system, and suppresses the digestive, reproductive and growth systems. This complex natural alarm system also communicates with the brain regions that control mood, motivation and fear. Once the "threat" has passed, the adrenaline and cortisol levels return to normal restoring the heart rate and blood pressure to normal, while other body systems resume their original activities.
However, if stress is constantly present and an individual "feels" under attack, or fearful or worried constantly, then the "fight-or-flight" response stays turned on. This overexposure to cortisol and other stress hormones can disrupt most all body processes. This puts an individual at increased risk of many health problems, including:
||Memory and focus issues
In several preliminary human studies, Laminine consumption reduced cortisol levels. The primary growth factor in the LifePharm Growth factor extract, (FGF2) supports neurological responses in areas of the brain known to reduce anxiety, influencing good mental and emotional responses. Scientists are observing that these responses are occurring at the genetic or DNA level. They are also observing that individuals who have suffered long-term, high stress conditions show greater deterioration of the DNA protective strands called Telomeres than normal people. A clinical study showed that subjects consuming Laminine (4 capsules/day) for ninety days had activated the DNA repair mechanism (telomerase enzyme) which restores telomere integrity and length. This is associated with better cell division or proliferation giving rise to restored tissues leading to healthier aging. High stressed individuals that care for a spouse with Alzheimer's disease, mothers raising handicapped children and combat war-veterans have shown in published studies to have shorter telomere length compared to matched control subjects.
Previously reported clinical and basic research studies ascertained that the Lifepharm dietary supplement formulas have nutritional ingredients that support helpful functions in the body. Providing all supplements in an inclusive convenient package encourages their regular daily consumption. It is noteworthy to observe beneficial clinical outcomes and safety occurring with use of all the supplements taken daily for ninety days.
Supporting cellular benefits and regeneration functions with the Laminine product is of great benefit to general repair and regeneration of healthy cells. An earlier study showed cholesterol and triglyceride lowering effects when both Laminine and Omega+++ were taken together rather than when OMEGA+++ was taken alone.
When Immune+++ was taken by subjects there was benefit to supporting an increase in total white blood cells, B cells and T cells in a previous pilot study. When taken with Laminine the effect was even greater showing that immune cells seemed to respond well with the IMMUNE+++ product but there was an enhanced effect when Laminine and IMMUNE+++ were taken together.
We also know the digestive system is key to optimal health in balancing proper digestive functions, and key to the immune system functions. Digestive+++ has been studied showing its benefit in improving the gut lining important for deterring pathogens or cellular by-products such as gluten, allergens or undigested food particles from leaking into the blood stream.
It is noteworthy to observe that taking all supplements together two Laminine, one Digestive+++, one IMMUNE+++ and one OMEGA+++ daily would benefit numerous body functions. Observing a high response in the typical parameters that are generally used to check for overall health after consuming the REFIVE packet daily for 3 months is encouraging. This investigation warrants further studies with larger study groups.
Directions for adult use: Take one packet of enclosed supplements daily. Observe information on box about ingredients. Product contains fish and egg so avoid if you are allergic to these. As with all dietary supplements, if you are ill, pregnant or lactating consult with your physician before use.